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培氟沙星(PFLX、培福新Pefloxacin)是氟喹诺酮类广谱抗菌药,作用快、疗效高、不良反应小,对革兰阳性菌、阴性菌均有较好的抗菌活性.我们自1995年1月～1996年4月使用法国罗纳-普朗克公司生产的培氟沙星治疗肺部感染186例,现将临床观察结果报告如下.1 材料与方法1.1 病例选择 本组186例中176例为住院病人,10例为门诊病人,均经临床、X线、实验室等检查确诊为肺部感染.男123例,女63例;年龄16～82岁,平均55岁.186例中肺炎100例,慢性支气管炎急性发作73例,支气管扩张并感染5例,支气管哮喘并感染3例,脓胸2例,自发性气胸并感染2例,肺脓肿1例.1.2 剂量与给药方法 培氟沙星注射液400mg+5%葡萄糖液250ml静脉滴注,每日2次,连用5～10天后改为400mg,每日1次,12小时后口服培氟沙星片400mg,总疗程7～14天.
Pefloxacin (PFLX, Pefloxacin) is a fluoroquinolone broad-spectrum antibacterial agent with fast acting, high curative effect, small adverse reaction and good antibacterial activity against Gram-positive bacteria and negative bacteria. January to April 1996 in France Rhône-Planck produced pefloxacin 186 cases of pulmonary infection, the clinical observations are reported as follows.1 Materials and methods 1.1 Case Selection 186 cases of this group One hundred and sixty-six inpatients and 10 outpatients were diagnosed as pulmonary infection by clinical, X-ray and laboratory tests, including 123 males and 63 females, aged from 16 to 82 years (average 55 years) 100 cases of pneumonia, acute exacerbation of chronic bronchitis in 73 cases, bronchiectasis and infection in 5 cases, bronchial asthma and infection in 3 cases, empyema in 2 cases, spontaneous pneumothorax and infection in 2 cases, lung abscess in 1. 1 dose and administration Pefloxacin injection 400mg + 5% glucose 250ml intravenous infusion, 2 times daily, once every 5 to 10 days later changed to 400mg, 1 day, 12 hours after oral pefloxacin tablets 400mg, the total course of treatment 7 ~ 14 days.