天然存在的与合成的具有α-亚甲基-γ和δ-内酯骨架的化合物都具有细胞毒、抗炎、抗菌、降血脂等生物活性。然而,大多数这类化合物因其高度的反应性,在体内无选择性地和亲核细胞成份相互作用,故亦具有较大的毒性。曾通过连接适当的载体,如糖或甾体,或利用其衍生物,如α-亚甲基-γ-丁内酯磺 Naturally occurring and synthetic compounds with [alpha] -methylene- [gamma] and [delta] -lactone backbones all possess cytotoxic, anti-inflammatory, antibacterial, hypolipidemic and other biological activities. However, most of these compounds are also highly toxic because of their high degree of reactivity, which selectively interacts with nucleophilic cellular components in the body. This is achieved by attaching a suitable carrier, such as a sugar or steroid, or using its derivatives, such as [alpha] -methylene- [gamma] -butyrolactone sulfonate