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目的:探讨高频振荡通气与常频机械通气交替应用治疗早产儿呼吸窘迫综合征的疗效。方法:选取泰安市妇幼保健院2015年4月至2017年8月收治的早产儿呼吸窘迫综合征174例进行研究，采用随机数字表法将其分为三组，常频组采用常频机械通气治疗，高频组采用高频振荡通气治疗，交替应用组联合常频机械通气与高频振荡通气治疗，治疗后比较三组患儿用氧时间、机械通气时间、氧合功能、并发症及存活情况。结果:交替应用组用氧时间及机械通气时间均较常频组和高频组短，差异均有统计学意义(均n P<0.05)。治疗开始后各组患儿动脉血氧分压(PaOn 2)与动脉血氧分压与吸入氧浓度比(PaOn 2/FiOn 2)增高，动脉血二氧化碳分压(PaCOn 2)、氧合指数(OI)与呼吸指数(RI)降低，与治疗前比较差异均有统计学意义(均n P<0.05)。治疗12 h、24 h及48 h时交替应用组PaOn 2与PaOn 2/FiOn 2高于常频组与高频组，PaCOn 2、OI与RI低于常频组与高频组，差异均有统计学意义(均n P0.05)。n 结论:高频振荡通气与常频机械通气交替应用治疗早产儿呼吸窘迫综合征有利于提高氧合功能，缩短用氧时间与机械通气时间，安全性良好。“,”Objective:To investigate the alternate application efficacy of high-frequency oscillatory ventilation and constant-frequency mechanical ventilation in the treatment of premature infants with respiratory distress syndrome.Methods:From April 2015 to August 2017, 174 premature infants with respiratory distress syndrome were chosen in this research and randomly divided into three groups.CF group was treated with constant-frequency mechanical ventilation, HF group was treated with high-frequency oscillatory ventilation, AP group was treated with alternate application of constant-frequency mechanical ventilation and high-frequency oscillatory ventilation.After treatment, the oxygen time, mechanical ventilation time, oxygenation, complications and survival in the three groups were compared.Results:The oxygen time, mechanical ventilation time of the AP group were shorter than those of the HF group and the CF group, the differences were statistically significant (all n P<0.05). After treatment, the PaOn 2 and PaOn 2/FiOn 2 were increased in each group, and the PaCOn 2, OI and RI were decreased, and the differences were statistically significant compared with before treatment (all n P<0.05). At 12 h, 24 h and 48 h after treatment, the PaOn 2 and PaOn 2/FiOn 2 in the AP group were higher than those in the CF group and the HF group, the PaCOn 2, OI and RI were lower than those in the CF group and the HF group(all n P0.05).n Conclusion:Alternate application of high-frequency oscillatory ventilation and constant-frequency mechanical ventilation in the treatment of premature infants with respiratory distress syndrome can improve oxygenation, shorten oxygen time and mechanical ventilation time, with good safety.