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目的 了解神经内科住院老年患者艰难梭菌 (Clostridiumdifficile ,CD)小区域暴发流行的情况。方法 对我院神经内科一起暴发流行艰难梭状芽胞杆菌相关性腹泻 (CDAD)的 5例老年患者进行了回顾性调查。结果 5例艰难的梭状芽胞杆菌相关性腹泻患者占同期神经内科住院患者的 3.5 7% (5 / 140 ) ;其中轻型 1例 ,重型 1例 ,暴发型 3例 ;痊愈 3例 ,死亡 2例。结论 老年住院患者、抗生素使用及严重的基础疾病、气管切开和鼻饲是导致艰难梭菌感染的高危因素。区域性丛集分布的患病人群提示有外源性交叉感染的可能。暴发型艰难梭状芽胞杆菌感染患者病情进行迅猛 ,并发症严重 ,预后极差。
Objective To understand the prevalence of Clostridium difficile (CD) in outpatients in neurology department. Methods A retrospective investigation was performed on 5 elderly patients with outbreak of Clostridium difficile-associated diarrhea (CDAD) in our department of neurology. Results Five patients with difficult Clostridium difficile-associated diarrhea accounted for 3.57% (5/140) of hospitalized neurology patients in the same period. Among them, 1 was mild, 1 was severe and 3 was fulminant; 3 patients were cured and 2 died . Conclusion Elderly hospitalized patients, antibiotics and severe underlying diseases, tracheostomy and nasal feeding are risk factors for C. difficile infection. The prevalence of regional cluster distribution of the population suggests the possibility of exogenous cross-infection. Outbreaks of Clostridium difficile infection in patients with rapid disease, serious complications, poor prognosis.