Med Assoc J.-1992,147(9).-1308～1309饮食中的铝与早老性痴杲有关。铝是一种普遍存在的元素,因此确定影响铝生物利用率的因素非常重要。已知磷酸盐、铁和氟具有降低铝生物利率的作用,而柠檬酸、调味剂麦芽酚、甲状旁腺激素和膳食维生素 D 却具有提高铝生物利用率的作用。有人研究了铝吸收、钙营养状况、维生素 D 摄入量与甲状旁腺激素的相互关系。甲状旁腺刺激肾中1,25-二羟基维生素 D_3合成,后者又促进铝的肠道吸收。实验证明,补充维生素 D 的受试动物体内铝的水平增加。大脑中铝的蓄积似乎也受维生素 D 的影响。然而膳食维生素 D 对铝的影响远不及内源性1,25-二羟基维生素 D_3。作者认为,如果有进一步的证据证实维 Med Assoc J.-1992, 147 (9) .- 1308 ~ 1309 Aluminum in the diet is associated with pre-eclampsia. Aluminum is a ubiquitous element and therefore determining the factors that affect the bioavailability of aluminum is very important. Phosphates, iron and fluorine are known to reduce aluminum bioavailability while citric acid, flavoring maltol, parathyroid hormone, and dietary vitamin D have the effect of increasing aluminum bioavailability. Someone studied the relationship between aluminum absorption, calcium status, vitamin D intake and parathyroid hormone. Parathyroid stimulates the synthesis of 1,25-dihydroxyvitamin D3 in the kidney, which in turn promotes the intestinal absorption of aluminum. Experiments show that vitamin D supplementation in animals increased the level of aluminum. The accumulation of aluminum in the brain seems to be affected by vitamin D. However, the impact of dietary vitamin D on aluminum is far less than the endogenous 1,25-dihydroxy vitamin D_3. The author believes that if there is further evidence to confirm the dimension