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以β-环糊精为单体,环氧氯丙烷为交联剂,通过反相乳液聚合法和共沉淀法制备了盐酸小檗碱β-环糊精聚合物微球(BH-β-CDPM)。多媒体显微镜验证了β-CDPM的球形结构;紫外光谱分析研究表明,通过共沉淀法制备的微球对BH的包载性能较优,BH-β-CDPM的包封率最大为69.45%;通过对BH-β-CDPM的体外释药行为研究,发现介质的pH值对其释药效果影响较大,在碱性介质(pH=9.9)中缓释性能较好,中性介质释放较快,且药物投加量越低缓释越显著。BH-β-CDPM(30∶1)在pH=2.2的介质中药物的释药动力学过程附合Higuchi和Korsmeyer-Peppas模型,可见该条件下药物的释放主要是Fikc扩散过程。
Using β-cyclodextrin as monomer and epichlorohydrin as crosslinking agent, berberine hydrochloride β-cyclodextrin polymer microspheres (BH-β-CDPM) were prepared by inverse emulsion polymerization and coprecipitation ). The microstructure of β-CDPM was verified by a multi-media microscope. The results of UV spectroscopy showed that the microspheres prepared by coprecipitation method exhibited better encapsulation efficiency for BH, and the encapsulation efficiency of BH-β-CDPM was 69.45% BH-β-CDPM in vitro release behavior and found that the pH value of the medium on the release of its greater impact on the alkaline medium (pH = 9.9) better sustained release performance, neutral medium release faster, and The lower dosage of drug slow release more significant. The release kinetics of BH-β-CDPM (30:1) in the medium of pH = 2.2 was fitted with Higuchi and Korsmeyer-Peppas models. The release of the drug under this condition was mainly Fikc diffusion.