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The heat shock protein 70 family member mortalin(mot-2)/mthsp70/PBP74/GRP75 is highly expressed in cancer cells with special perinuclear cellular distribution.As a chaperon protein,mortalin has multiple subcellular localizations and binding partners and its functions involve in mitochondria input,energy generation,intracellular trafficking,and receptor internalization.Most importantly,mortalin contributes to carcinogenesis by sequestrating key tumor suppressor p53 in the cytoplasm and inactive its transcriptional and non-transcriptional apoptotic function.The present article tries to summarize the recent findings on mortalin’s role in carcinogenesis and proposes it as a potential target for cancer therapy.
The heat shock protein 70 family member mortalin (mot-2) / mthsp70 / PBP74 / GRP75 is highly expressed in cancer cells with special perinuclear cellular distribution. As a chaperon protein, mortalin has multiple subcellular localizations and binding partners and its functions involved in mitochondria input, energy generation, intracellular trafficking, and receptor internalization. M importantly, mortalin contributes to carcinogenesis by sequestrating key tumor suppressor p53 in the cytoplasm and inactive its transcriptional and non-transcriptional apoptotic function. The present article tries to summarize the recent findings on mortalin’s role in carcinogenesis and proposes it as a potential target for cancer therapy.