The aim of this study is to prepare a PVA-GAG-COL composite material by polyvinyl alcohol (PVA), glycosaminoglycan (GAG) and collagen (COL),and to inves-tigate the feasibility of serving as a scaffold for tissue engineering. PVA was blended with various amounts of GAG and COL. Different proportional scaffolds could be obtained with different molecular weight and alcoholysis degree of PVA and different amounts of GAG, which exhibited high water content (60%-95%) and showed different inner configura-tion with swelling ratio (120%-620%). SEM proved that different composite materials had different porous structures.