以1-萘酚-3,6-二磺酸钠和2,4-二硝基氟苯为原料,通过亲核取代反应制备出侧链磺化二硝基化合物,再经SnCl2/HCl还原反应得到侧链型磺化二胺1-(2,4-二氨基苯氧基)-3,6-萘二磺酸,两步反应总收率为32%。产物结构经IR、1HNMR确认。亲核取代反应的条件研究表明,在二甲基亚砜中室温反应24 h,可制备出液相色谱纯度为98%的侧链磺化二硝基化合物,反应收率为50%。 A side chain sulfonated dinitro compound was prepared by nucleophilic substitution reaction using sodium 1-naphthol-3,6-disulfonate and 2,4-dinitrofluorobenzene as raw materials, followed by reduction with SnCl2 / HCl The side chain sulfonated diamine 1- (2,4-diaminophenoxy) -3,6-naphthalene disulfonic acid was obtained. The total yield of the two steps was 32%. The product structure was confirmed by IR, 1HNMR. The conditions of nucleophilic substitution reaction showed that the side chain sulfonated dinitro compound with 98% purity was prepared in dimethylsulfoxide at room temperature for 24 h. The yield of the reaction was 50%.