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弥漫性轴索损伤(diffuse axonal injury,DAI)是头部受钝性外力作用引起的以神经轴索断裂为特征的脑白质多发性损伤,在重型颅脑损伤中占28％～42％,死亡率达42％～62％[1]。在法医检案中,交通事故、高坠和暴力所致颅脑损伤常发生DAI。也有报道,婴儿头部受到摇晃后发生DAI。如何能确切并尽早地对DAI定性并探明其形成机制,一直是中外学者研究的热点。1动物模型1.1旋转负荷动物模型 Gennarelli[2]将狒狒头颅于冠状面在11～22ms内旋转60度后,在胼胝体、内囊、脑干上端与大脑白质区检见轴索损
Diffuse axonal injury (DAI) is a multiple brain injury characterized by axonal rupture caused by blunt external force, accounting for 28% -42% of severe craniocerebral injury and death Rate of 42% to 62% [1]. In forensic medical examination, DAI occurs frequently in traumatic brain injury caused by traffic accidents, high falls and violence. It has also been reported that DAI occurs after the baby’s head is shaken. How to characterize DAI and determine its formation mechanism exactly and early has always been a hot topic both in China and abroad. 1 animal model 1.1 Rotational Animal Model Gennarelli [2] the head of the baboon in the coronal plane in the rotation of 60 degrees within 11 ~ 22ms, the corpus callosum, internal capsule, the upper brain stem and brain white matter area to see axial damage