论文部分内容阅读
[目的]]观察活血化痰解毒汤联合还原性谷胱甘肽治疗湿热瘀毒型重症肝炎疗效。[方法]使用随机平行对照方法,将132例住院患者按病志号抽签方法简单随机分为两组。对照组66例抗病毒,葡醛内酯,促肝细胞生成素、维生素C等,还原型谷胱甘肽1.2g+0.9%氯化钠100m L,静滴,1次/d。治疗组66例活血化痰解毒汤(茵陈、金钱草各30g,鸡内金、桃仁、赤芍、丹参各20g,大黄10g,栀子、蒲公英各15g,生甘草3g),水煎300m L,1剂/d,3次/d;西药治疗同对照组。连续治疗1个月为1疗程。观测临床症状、谷丙转氨酶(ALT)、谷草转氨酶(AST)、胆碱酯酶(CHE)、总胆红素(TB)、直接胆红素(DB)、凝血酶原时间(PT)、白蛋白(Aib)、不良反应。连续治疗2疗程,随访3个月,判定疗效。[结果]ALT、AST两组均有改善(P<0.01),治疗组改善优于对照组(P<0.05),CHE两组均无明显变化(P>0.05);总胆红素(TB)、直接胆红素(DB)治疗组均明显改善(P<0.01),对照组无明显变化(P>0.05);PT治疗组均明显改善(P<0.01),对照组无明显变化(P>0.05);Aib两组均有改善(P<0.01,P<0.05),治疗组改善优于对照组(P<0.01)。[结论]活血化痰解毒汤联合还原性谷胱甘肽治疗湿热瘀毒型重症肝炎,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the curative effect of Huoxue Huatan Jiedu Decoction combined with reduced glutathione for the treatment of severe hepatitis with damp heat and blood stasis. [Methods] Using randomized parallel control method, 132 inpatients were randomly divided into two groups randomly according to the method of lot drawing. The control group of 66 cases of antiviral, glucurolactone, pro-hepatopoietin, vitamin C, etc., reduced glutathione 1.2g +0.9% sodium chloride 100m L, intravenous infusion, 1 time / d. The treatment group, 66 cases of promoting blood circulation phlegm detoxification soup (capillaris, 30 grams of money grass, chickens gold, peach kernel, red peony root, Salvia 20g, rhubarb 10g, gardenia, dandelion 15g, raw licorice 3g), decoction 300m L , 1 / d, 3 times / d; Western medicine treatment with the control group. Continuous treatment for 1 month for a course of treatment. The clinical symptoms, ALT, CHE, TB, DB, PT, Protein (Aib), adverse reaction. Continuous treatment of 2 courses, followed up for 3 months to determine the efficacy. [Results] The levels of ALT and AST in both groups were improved (P <0.01), and the improvement in the treatment group was better than that in the control group (P <0.05). There was no significant difference between the two groups (P> 0.05) (P <0.01), but there was no significant change in the control group (P> 0.05). PT treatment group was significantly improved (P <0.01), but there was no significant difference in the control group (P> 0.05) .Aib improved in both groups (P <0.01, P <0.05), and the treatment group improved better than the control group (P <0.01). [Conclusion] Huoxue Huatan Jiedu Decoction combined with reducing glutathione in the treatment of severe hepatitis with damp-heat and blood stasis poisoning has satisfactory curative effect and no serious adverse reactions, which deserves promotion.