乳腺癌是危害妇女健康的主要恶性肿瘤,其死亡原因几乎都是远处转移所致。因此,了解与乳腺癌转移有关的基因对乳腺癌转移的研究意义重大。Maspin基因为一种新发现的丝氨酸蛋白酶抑制剂最初由Zou等[1]用消减杂交(subtractive hybridiza-tion)技术对正常乳腺组织和乳腺癌组织进行 Breast cancer is a major malignant tumor that endangers the health of women. Almost all causes of death are distant metastases. Therefore, to understand the breast cancer metastasis-related genes on breast cancer metastasis of great significance. Maspin gene is a newly discovered serine protease inhibitor originally developed by Zou et al. [1] using subtractive hybridization on normal breast and breast cancer tissues