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目的探讨乳腺浸润性导管癌中表皮钙黏蛋白(E-cadherin,E-cad)的表达及其意义。方法选取2005年1月2009年12月的组织病理切块,用免疫组织化学EnVision二步法检测63例乳腺浸润性导管癌(invasiveductal carcinoma,IDC)组织中E-cad的表达情况,设为IDC组;另检测15例乳腺纤维腺瘤及15例乳腺小叶增生症乳腺组织中E-cad的表达情况,设为对照组;比较两组的E-cad表达。结果 E-cad在IDC组及对照组中表达阳性率分别为58.7%、80.0%;两组间差异有统计学意义(P<0.05)。在乳腺IDC患者中,年龄<38岁和≥38岁组的E-cad阳性表达率分别是54.2%、61.5%,两组间差异无统计学意义(P>0.05);肿块直径<3cm和≥3cm组的E-cad阳性表达率分别是54.8%、66.7%,两组间差异无统计学意义(P>0.05);组织学分级为Ⅰ+Ⅱ级和Ⅲ级组的E-cad阳性表达率分别是76.3%、32.0%,两组间差异有统计学意义(P<0.05);无、有腋窝淋巴结转移组的E-cad阳性表达率分别是78.3%、47.5%,两组间差异有统计学意义(P<0.05)。结论 E-cad的表达与患者年龄及肿块大小无关,而与组织学分级、淋巴结转移相关。在乳腺浸润性导管癌中,无淋巴结转移者E-cad表达高于有淋巴结转移者,提示E-cad是乳腺浸润性导管癌发生淋巴结转移的重要指标。
Objective To investigate the expression of E-cadherin (E-cad) in breast invasive ductal carcinoma and its significance. Methods Histopathological sections from January 2005 to December 2009 were collected. EnVision immunohistochemistry was used to detect the expression of E-cadherin in 63 cases of breast invasive ductal carcinoma (IDC) Group; the other 15 cases of breast fibroadenoma and 15 cases of breast lobular hyperplasia of breast tissue E-cad expression was set as the control group; E-cad expression was compared between the two groups. Results The positive rates of E-cad in IDC group and control group were 58.7% and 80.0%, respectively. There was significant difference between the two groups (P <0.05). In breast IDC patients, the positive expression rates of E-cad in age group <38 years old and ≥38 years old were 54.2% and 61.5% respectively, with no significant difference between the two groups (P> 0.05) The positive rates of E-cad in 3cm group were 54.8% and 66.7%, respectively. There was no significant difference between the two groups (P> 0.05). The positive expression rate of E-cad in group Ⅰ + Ⅱ and Ⅲ (76.3%, 32.0%, respectively). There was a significant difference between the two groups (P <0.05). The positive expression rate of E-cad in non-axillary lymph node metastasis group was 78.3% and 47.5%, respectively Significance (P <0.05). Conclusion The expression of E-cad has nothing to do with the patient’s age and tumor size, but is related to histological grade and lymph node metastasis. In invasive ductal carcinoma of the breast, the expression of E-cadherin in non-lymph node metastasis is higher than that in patients with lymph node metastasis, suggesting that E-cad is an important indicator of lymph node metastasis in invasive ductal carcinoma of the breast.