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目的研究奥美拉唑肠溶片在中国朝鲜族和汉族健康人体内的药动学。方法10名朝鲜族和10名汉族健康受试者,口服奥美拉唑肠溶片40mg,用高效液相色谱法测定血浆中奥美拉唑浓度,DAS ver2.0.1软件计算药动学参数。结果奥美拉唑肠溶片在朝鲜族和汉族受试者的主要药动学参数:ρmax分别为(828±s539)和(760±581)μg·L-1;tmax分别为(3.5±1.5)和(2.7±0.8)h;t1/2分别为(1.3±0.8)、(1.6±1.3)h;AUC0～12分别为(2635±2104)和(1438±798)μg·h·L-1;AUC0～∞分别为(2816±2419)和(1470±769)μg·h·L-1。结论朝鲜族与汉族受试者单剂量口服奥美拉唑肠溶片的药动学参数无统计学差异。
Objective To study the pharmacokinetics of omeprazole enteric-coated tablets in healthy Korean and Han Chinese. Methods 10 Korean and 10 Han healthy subjects were given 40 mg Omeprazole enteric-coated tablets. The plasma concentrations of omeprazole were determined by HPLC. Pharmacokinetic parameters were calculated by DAS ver2.0.1 software. Results The main pharmacokinetic parameters of omeprazole enteric-coated tablets were (828 ± s539) and (760 ± 581) μg · L-1, respectively, for Korean and Han subjects; tmax were (3.5 ± 1.5 ) And (2.7 ± 0.8) h respectively; t1 / 2 was (1.3 ± 0.8) and (1.6 ± 1.3) h respectively; AUC0-12 was (2635 ± 2104) and (1438 ± 798) μg · h · L -1 ; AUC0 ~ ∞ were (2816 ± 2419) and (1470 ± 769) μg · h · L-1, respectively. Conclusion There was no significant difference in the pharmacokinetic parameters of oral omeprazole enteric-coated tablets between Korean and Han subjects.