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目的探讨多囊卵巢综合征(PCOS)患者血清硫酸脱氢表雄酮(DHEA-S)及性激素结合球蛋白(SHBG)检测的临床意义。方法选取159例PCOS患者为实验组,136名健康女性为正常对照组,采用化学发光微粒子免疫分析法(CMIA)检测血清中DHEA-S、SHBG水平。结果 PCOS组血清DHEA-S水平(294.66±106.76)μg/dl明显高于正常对照组(254.47±76.18)μg/dl,差异有统计学意义(t=3.678,P<0.01)。PCOS组血清SHBG水平(45.45±21.63)nmol/L明显低于正常对照组(64.18±33.04)nmol/L,差异有统计学意义(t=-5.834,P<0.01)。PCOS组血清DHEA-S与SHBG之间存在负相关关系(r=-0.202,P<0.05)。结论 PCOS患者体内DHEA-S水平升高,SHBG水平降低,DHEA-S与SHBG联合检测对PCOS的诊断具有一定的参考价值。
Objective To investigate the clinical significance of detecting serum dehydroepiandrosterone (DHEA-S) and sex hormone binding globulin (SHBG) in patients with polycystic ovary syndrome (PCOS). Methods 159 patients with PCOS were selected as the experimental group and 136 healthy women as the normal control group. The levels of DHEA-S and SHBG in the serum were detected by chemiluminescence microparticle immunoassay (CMIA). Results The serum level of DHEA-S in PCOS group (294.66 ± 106.76) μg / dl was significantly higher than that in normal control group (254.47 ± 76.18) μg / dl, the difference was statistically significant (t = 3.678, P <0.01). The level of serum SHBG in PCOS group (45.45 ± 21.63) nmol / L was significantly lower than that in normal control group (64.18 ± 33.04) nmol / L, the difference was statistically significant (t = -5.834, P <0.01). PCOS serum DHEA-S and SHBG negative correlation (r = -0.202, P <0.05). Conclusions The level of DHEA-S and the level of SHBG in PCOS patients are decreased. Combined detection of DHEA-S and SHBG has some reference value for the diagnosis of PCOS.