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将各种阳离子化的抗原(人血清白蛋白、人免疫球蛋白G、马脾铁蛋白和人免疫球蛋白M)经静脉分别注入大鼠体内,用电镜和免疫荧光法观察抗原与鼠肾小球基底膜(GBM)结合的情况,通常在等电点>8.5～9.5时,抗原一般与GBM结合并迅速沉积于GBM,仅人免疫球蛋白M少量结合在肾小球毛细血管壁。静脉注入马脾铁蛋白,免疫复合物早期明显地沉积在内皮下,以后离解通过基底膜,重新形成复合物沉积在上皮下,免疫复合物一般经5分钟即出现,
A variety of cationized antigens (human serum albumin, human immunoglobulin G, horse spleen ferritin and human immunoglobulin M) were intravenously injected into the body of rats, electron microscopy and immunofluorescence method to observe the antigen and mouse kidney Ball basement membrane (GBM) binding, usually in the isoelectric point> 8.5 ~ 9.5, the antigen is generally combined with GBM and rapidly deposited in the GBM, only a small amount of human immunoglobulin M in the glomerular capillary wall. Intravenous injection of horse spleen ferritin, the immune complex early significantly deposited under the endothelium, after dissociation through the basement membrane, the formation of complex deposition in the epithelium, the immune complexes generally appear after 5 minutes,