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越来越多的证据提示急性和慢性肝炎的肝脏损害是通过免疫机制引起。慢性活动性肝炎中的自身抗体及急性和慢性肝炎中乙型肝炎病毒抗原-抗体系统的研究,均证实了有体液免疫参予。在急性和慢性肝炎中,发现在分离出的人肝细胞浆膜上有体内固定于该处的免疫球蛋白,提示为抗体依赖性细胞的细胞毒反应。慢性活动性肝炎患者的淋巴细胞对各种靶细胞的免疫反应已有报告。现有的知识似乎支持这样的观点,即在急性或慢性乙型肝炎的病程中,不是乙型肝炎病毒本身,而是抗病毒或细胞膜抗原的免疫反应起真正的致病作用。通过血清试验,现已可能把健康的HBsAg携带者和HBsAg阳性的慢性肝炎患者区分开来。HBsAg阳
There is growing evidence that liver damage in acute and chronic hepatitis is caused by immune mechanisms. Autoimmune antibodies in chronic active hepatitis and hepatitis B virus antigen-antibody systems in both acute and chronic hepatitis confirmed the presence of humoral immunity. In acute and chronic hepatitis, it is found that there is an immunoglobulin that is immobilized on the isolated plasma membrane of human liver cells, suggesting an antibody-dependent cellular cytotoxicity. Immune responses of lymphocytes to various target cells in patients with chronic active hepatitis have been reported. Current knowledge seems to support the notion that in the course of acute or chronic hepatitis B, not the hepatitis B virus itself, but the true pathogenic effects of the immune response to the anti-viral or cell membrane antigens. By serum tests, it is now possible to distinguish between healthy HBsAg carriers and HBsAg-positive patients with chronic hepatitis. HBsAg positive