近年来,谷氨酰胺(Gln)作为特殊的免疫营养素成为各学科领域的研究热点,尤其在机体应激状态下对维护肠道结构和免疫功能的完整性具有不可替代的作用。因此,Gln被认为是应激状态下的“条件必需氨基酸”。肠道作为危重病应激的中心器官和MODS的始动器[1],使人们逐步重视肠道功能在病人整体病理过程中的作用。本文将Gln对肠道免疫屏障功能的保护作用的研究进展做一综述。 In recent years, glutamine (Gln) as a special immunonutrient has become a research hotspot in various fields, especially in the body stress state has an irreplaceable role in maintaining the integrity of the intestinal structure and immune function. Therefore, Gln is considered as a “conditioned essential amino acid” under stress. Intestinal tract as critical stress-induced central organ and MODS initiators [1], so that people gradually focus on intestinal function in the overall pathological role of the patient. This article reviews the research progress of Gln on the protective function of intestinal immune barrier.