糖尿病患者在病程中出现蛋白尿,一般认为属不良之兆。在这些病人中有很高的比例,在五年内进展到肾衰竭,若不作维持血透或移植可因而致命。糖尿病肾病的最常见组织学损害是弥漫性或结节性肾小球硬化和小动脉透明变性。虽然,其他类型的原发性肾小球病变引起蛋白尿和影响肾功能不全,在糖尿病中较为少见。但确定这些不同的病变,显然对预后和治疗均有意义。作者报告3例糖尿病伴肾病综合征的临床和化验特征(表1)。肾活检材料作光镜、电镜和免疫荧光 Diabetic patients with proteinuria in the course of the disease, generally considered to be a sign of bad. A high proportion of these patients progress to renal failure within five years and are fatal if they do not maintain hemodialysis or transplant. The most common histologic lesions of diabetic nephropathy are diffuse or nodular glomerulosclerosis and arteriolar degeneration. Although other types of primary glomerular lesions cause proteinuria and affect renal insufficiency, it is less common in diabetes. However, to determine these different lesions, it is clear that prognosis and treatment are meaningful. The authors report the clinical and laboratory features of 3 diabetic patients with nephrotic syndrome (Table 1). Renal biopsy material for light microscopy, electron microscopy and immunofluorescence