手性药物在生物体内具有不同的代谢途径和药理作用,产生药代动力学和药效学立体选择性差异,导致生理作用存在极大差别,因此手性药物的拆分在生命科学、医药工业等领域中具有非常重要的作用。薄层色谱(TLC)是最简便的色谱技术之一,具有操作方便、设备简单、分离效率高、分析速度快、色谱参数易调整等特点,在对映体的分离中具有实用意义。用TLC进行手性分离的方式主要 Chiral drugs in the body have different metabolic pathways and pharmacological effects, resulting in pharmacokinetic and pharmacodynamic stereoselective differences, resulting in a great difference in the physiological role, the separation of chiral drugs in the life sciences, the pharmaceutical industry And other fields has a very important role. Thin layer chromatography (TLC) is one of the simplest chromatographic techniques. It has the advantages of easy operation, simple equipment, high separation efficiency, fast analysis and easy adjustment of chromatographic parameters. It has practical significance in the separation of enantiomers. Chiral separation by TLC method