腺样囊性癌、前列腺癌等易局部复发和沿神经束转移,影响临床疗效和预后,其沿神经浸润的发生机制一直是亟待解决的课题。本文对肿瘤沿神经浸润发生机制中相关的神经生长因子、基质金属蛋白酶和神经粘附分子的生物学作用。在相关肿瘤中的表达及检出情况、介导肿瘤浸润行为等作一综述。 Adenoid cystic carcinoma, prostate cancer and other local recurrence and nerve bundle transfer, affecting the clinical efficacy and prognosis, along its mechanism of infiltration has been a problem to be solved. In this article, we investigate the biological role of tumor-associated neural growth factors, matrix metalloproteinases and neural adhesion molecules in the mechanism of neural invasion. In the related tumor expression and detection of the situation, mediated tumor infiltration behavior are reviewed.