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目的探讨孕中期孕妇血清标志物甲胎蛋白(AFP)和游离人绒毛促性腺激素β亚单位(Free-βhCG)和雌三醇(uE3)检测在产前筛查中的作用。方法应用时间分辨荧光免疫分析系统对21 568例孕中期(14～20+6周)妇女进行血清AFP、uE3和Free-βhCG的检测及分析,风险率≥1∶270为唐氏综合征筛查高风险,追踪胎儿和孕妇的情况,产前诊断及新生儿检查以确认。结果 21 568例筛查孕妇中,唐氏综合征筛查高风险1392例,检出6例21三体,18-三体3例,其他异常染色体36例。胎儿异常检出率为2.59%。结论孕中期产前筛查是预测异常胎儿和不良妊娠结局的有效方法,再结合产前诊断对防止先天缺陷有实用性价值。
Objective To explore the role of serum alpha-fetoprotein (AFP) and free-β hCG and uE3 in prenatal screening in prenatal screening. Methods Serum AFP, uE3 and Free-β hCG were detected and analyzed in 21 568 second trimester women (14-20 + 6 weeks) using the time-resolved fluorescence immunoassay system. The risk ratio of ≥1: 270 was screening of Down’s syndrome High-risk, follow-up of fetuses and pregnant women, prenatal diagnosis and neonatal examination to confirm. Results Among 21 568 pregnant women who were screened, Down syndrome was 1392 high-risk patients. Twenty-one trisomy 21, 3 trisomy 18 and 36 other abnormal chromosomes were detected. Fetal anomaly detection rate was 2.59%. Conclusion The prenatal screening in the second trimester is an effective method to predict the outcome of abnormal fetuses and adverse pregnancy. Combined with prenatal diagnosis, it is of practical value to prevent birth defects.