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自体LAK细胞回输治疗慢性活动型乙型肝炎(CAH)40例,疗程结束时,治疗组HBeAg和HBVDNA转阴率分别为22.5%和40%,与对照组相比差异显著(P均<0.001)。疗程结束12个月复查HBeAg、HBV DNA转阴率分别达到40%和68.57%。LAK治疗后患者IL—2水平及IL—2R表达均较治疗前明显升高(P均<0.01)。尤以HBeAg转阴者,IL—2升高更显著(P<0.005)。作者据此对治疗机制进行了探讨。
Autologous LAK cells were transfused in 40 patients with chronic active hepatitis B (CAH). At the end of treatment, the negative rates of HBeAg and HBVDNA in the treatment group were 22.5% and 40%, respectively, which were significantly different from those in the control group (all P <0.001) ). HBeAg was reexamined 12 months after the end of treatment, and the negative rates of HBV DNA reached 40% and 68.57% respectively. The levels of IL-2 and IL-2R in patients with LAK were significantly higher than those before treatment (all P <0.01). Especially HBeAg negative people, IL-2 increased more significantly (P <0.005). Based on this, the author discusses the treatment mechanism.