皮质类固醇常用于吸烟者COPD的治疗,但对无哮喘的吸烟者支气管高反应性(BHR)有何作用所知甚少,因此用双盲交叉对照试验进行了研究。患者和方法 14例中年男性吸烟者,无明显哮喘特征,吸入组胺均可致BHR,提示有轻度气道阻塞(平均FEV_1 2.42L)。有鼻花粉过敏史及皮试阳性者除外。受试者以前均未接受支气管舒张药物或其它治疗。以患者站立时的最高FEV_1为基值。雾化吸入 Corticosteroids are commonly used in the treatment of smokers with COPD, but little is known about the role of bronchial hyperresponsiveness (BHR) in asthmatic smokers, so a double-blind crossover study was performed. Patients and Methods Fourteen middle-aged male smokers showed no sign of asthma. Histamine inhalation induced BHR, suggesting mild airway obstruction (mean FEV 1 2.42L). There is a history of nasal pollen allergies and skin test positive except. Subjects had not previously received bronchodilator medications or other treatments. Based on the highest FEV_1 when the patient is standing. aerosol inhalation