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对62例慢乙肝患者T淋巴细胞亚群及NK细胞检测,并观察分别经iRNA、猪苓多糖及LAK细胞治疗前后的细胞数量变化。结果发现治疗前CD_4~+细胞降低,CD_8~+细胞增高,CD_4~+/CD_8~+比值下降。治疗后CD_4~+细胞及NK细胞增高,CD_4~+/CD_8~+比值上升。其中以LAK细胞治疗效果显著,与HBVM转阴呈正相关,说明提高机体免疫功能对清除病毒有一定作用。
T lymphocyte subsets and NK cells in 62 patients with chronic hepatitis B were detected and the changes of cell number before and after treatment with iRNA, Polyporus umbellatus and LAK cells were observed. The results showed that CD_4 ~ + cells decreased, CD_8 ~ + cells increased and CD_4 ~ + / CD_8 ~ + ratio decreased before treatment. After treatment, CD_4 ~ + cells and NK cells increased, and the ratio of CD_4 ~ + / CD_8 ~ + increased. Among them, the effect of LAK cell therapy was significant, and HBVM negative was positively correlated, indicating that improving the body’s immune function to clear the virus has a certain effect.