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近年来随着肿瘤分子生物学的发展,发现起源于非内分泌组织的恶性肿瘤可分泌各种的激素,称之为异位激素,其中不少可产生临床症状——即异位激素综合征。异位激素及异位激素综合征不仅对揭示肿瘤的分化调节具有重要的理论和实践意义,而且对许多潜在肿瘤的诊断、预后、考核疗效、判断有无复发等也有重要的临床意义。 异位柯兴氏综合征 1.发病原理 由于瘤细胞分泌异位促肾上腺皮质激素(ACTH)或ACTH类激素,导致肾上腺皮质增生,分泌过多的皮质类固醇,尤其是糖皮质激素。Upton等又在胰和肺肿瘤中检出促使ACTH
In recent years, with the development of molecular biology of tumors, it has been found that malignant tumors originating from non-endocrine tissues can secrete various hormones called ectopic hormones, many of which can produce clinical symptoms, namely ectopic hormone syndrome. Ectopic hormones and heterotopic hormone syndromes not only have important theoretical and practical significance in revealing the differentiation and regulation of tumors, but also have important clinical significance for the diagnosis, prognosis, assessment of efficacy, and judgment of recurrence of many potential tumors. Ectopic Cushing’s syndrome 1. Pathogenesis The tumor cells secrete ectopic adrenocorticotropic hormone (ACTH) or ACTH hormones that cause adrenal hyperplasia and excessive secretion of corticosteroids, especially glucocorticoids. Upton et al. also detected ACTH in pancreatic and lung tumors.