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本文观察了正常皮肤及3种皮损组织中的肥大细胞,发现肥大细胞在不同情况下形态学上有改变。为了对这些变化作出客观的定量分析,作者结合电子显微镜及形态定量分析方法对肥大细胞作了研究。对照标本取自3名新生儿及一名婴儿的包皮,2名成人尸体及1名正常成人的躯干皮肤。皮损标本取自2例系统性肥大细胞增生症,1例基底细胞癌(BCC)及1例血管瘤,均系成人。电镜观察并照相,每例至少检测30个肥大细胞。电镜照片输入带电子计算机的图象分析仪,检测每一肥大细胞的细胞总面积,核面积、颗粒数目及颗粒直径,并用方差分析法及双尾 t 检验法对实验数据进行统计学评价。
In this study, mast cells in normal skin and three kinds of lesions were observed, and mast cells were found to have morphological changes in different conditions. To make an objective quantitative analysis of these changes, the authors studied mast cells in combination with electron microscopy and morphometric quantitative analysis methods. The control specimens were taken from the foreskins of 3 newborns and 1 infant, the trunks of 2 adults and the trunk skin of a normal adult. Lesions were obtained from 2 cases of systemic mastocytosis, 1 case of basal cell carcinoma (BCC) and 1 case of hemangiomas, all adults. Observe and photograph with electron microscopy, and examine at least 30 mast cells in each case. Electron micrographs were imported into an image analyzer with an electronic computer. The total cell area, nuclear area, number of particles, and particle diameter of each mast cell were examined. Statistical analysis was performed using the analysis of variance and two-tailed t test.