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本文旨在评价b型流感杆菌（Hib）菌苗和13种百日咳无细胞菌苗DTP（DTaP）或2种百日咳全细胞菌苗DTP（DTP）联合免疫后Hib菌苗对DTaP或DTP的安全性和免疫原性的影响。 当第一种Hib菌苗——b型流感杆菌寡糖结合菌苗（HbOC）获准在婴儿中使用时,对13种DTaP和2种DTP的安全性和免疫原性的大规模多中心研究已在婴儿中完成了部分接种。此后在每次接种DTaP或DTP的同时在婴儿的另一侧大腿接种HbOC。
This article aims to evaluate the safety of Hib vaccine against DTaP or DTP after combination of Hib vaccine with 13 B. pertussis cell-free bacterins DTP (DTaP) or 2 B. pertussis whole-cell vaccine DTP (DTP) And immunogenicity. Large-scale multicenter studies of the safety and immunogenicity of 13 DTaP and 2 DTPs have been made when the first Hib vaccine, the type B influenza B oligosaccharide-binding bacterin (HbOC), is approved for use in infants Partial vaccination completed in infants. HbOC was then inoculated into the other thigh of the baby with each DTaP or DTP inoculation.