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目的 观察海捷亚 (氯沙坦 /氢氯噻嗪 )对高血压患者 2 4h血压的控制作用。方法 从心内科门诊及病房高血压患者中通过用 2 4h动态血压监测 ,观察 2 5例以血压超负荷为特征的原发性高血压患者。治疗开始前行 2 4h动态血压监测 ,服药之前当日记录门诊偶测血压。海捷亚每日晨服用 1片 ,服药第 1,2 ,4周分别记录门诊偶测血压 ,第 4周结束时再次行 2 4h动态血压监测。结果 所有患者服用海捷亚 1周后白天门诊偶测血压已开始降低 (P <0 0 5 ) ,第 2周后血压水平继续降低 ,第 4周结束时白天偶测血压值降低有非常显著性 (P <0 0 1)。第 4周动态血压监测与治疗前相比 ,白昼收缩压 (SBP) >14 0mmHg和舒张压 (DBP) >90mmHg读数的百分数 ,夜间SBP >12 0mmHg和DBP >80mmHg的读数百分数均明显下降 (P <0 0 5 )。第 4周的夜间血压下降百分率较治疗前升高(P <0 0 5 )。结论 海捷亚有快速、稳定的降压疗效 ,能明显减轻白昼及夜间血压超负荷 ,并对血压昼夜节律的恢复有调节作用
Objective To observe the control effect of Hypertension (losartan / hydrochlorothiazide) on blood pressure in patients with hypertension at 24 hours. Methods Twenty-five patients with essential hypertension characterized by blood pressure overload were observed from ambulatory clinic and ward hypertensive patients by using 24 h ambulatory blood pressure monitoring. 24 hours before treatment, ambulatory blood pressure monitoring, taking the day before the clinic record occasional blood pressure. Hytera used a daily morning 1, take the first two weeks, four weeks were recorded occasional blood pressure measured at the end of the fourth week again 24 hours ambulatory blood pressure monitoring. Results All patients took Hajeton one day after the clinic daytime occasional blood pressure began to decrease (P <0 05), after 2 weeks the level of blood pressure continued to decrease the end of the fourth week measured daytime occasional blood pressure decreased very significant (P <0 0 1). Ambulatory blood pressure monitoring at Week 4 The percentage of SBP> 14 0 mmHg and DBP> 90 mmHg readings, the percent SBP> 120 mmHg and DBP> 80 mmHg readings were significantly decreased (P <0 0 5). The percentage of nocturnal blood pressure decrease in the fourth week was higher than that before treatment (P <0.05). Conclusion Hytera has a rapid and stable antihypertensive efficacy, can significantly reduce the day and night blood pressure overload, and regulate the recovery of blood pressure circadian rhythm