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本文作者总結了近年来几种广譜抗菌素——包括四圜案族抗菌素和氯霉素的应用經驗和毒性問題。現将有关四圜素族抗菌素(金霉素、土霉素、四圜素及6-去甲基金霉素)的使用問题摘述于下: 四圜素族抗菌素优点很多,如毒性小,在机体內耐量好,疗效高。药品本身稳定,适合于口服,服后能被胃、十二指腸、回腸吸收,但大腸很少吸牧。药物被吸收后主要存在于血浆,还出現于巩膜、角膜、虹膜、玻璃体液、唾液,如系孕妇能通过胎盘到嬰儿,也出現于脊髓液中,但較在血中的浓度低。金霉素在胆汁中浓度高8～16倍于在血中的浓度,去甲基金霉素也较集中于肝及胆汁。这些药对快速生长的組織如肝,瘤細胞,还有新骨的亲和力較大,所以有人企图用此族抗菌素治胃癌。
The authors summarize the experience and toxicity of several broad-spectrum antibiotics in recent years, including the tetracycline antibiotics and chloramphenicol. The use of tetracycline antibiotics (chlortetracycline, oxytetracycline, tetracycline and 6-desmethylcultivarycin) is now summarized in the following: Tetrahedron antibiotics have many advantages, such as low toxicity, in the In vivo tolerance, high efficacy. The drug itself is stable, suitable for oral administration, after serving can be the stomach, duodenum, ileum absorption, but the small intestine suction animal husbandry. After the drug is absorbed mainly in the plasma, but also in the sclera, cornea, iris, vitreous humor, saliva, such as pregnant women through the placenta to the baby, also appeared in the spinal fluid, but lower than the concentration in the blood. Chlortetracycline concentration in the bile 8-16 times higher in the blood concentration, demethicillin is also more concentrated in the liver and bile. These drugs on the rapid growth of tissues such as liver, tumor cells, and new bone greater affinity, so some people attempt to use this group of antibiotics cure stomach cancer.