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使用干扰素α(IFN)制剂引起的某些功能状态,以及在特殊情况下发生企图自杀的病例,在药物使用说明书上已有记载,应引起医务工作者的注意。至今,由于使用干扰素α致企图自杀的病例已有32例,其中12例自杀身亡,今后更应唤起医务工作者的警惕。药物与企图自杀之间的关系,以往较多地考虑原有疾病、既往史、患者的性格等各种不明因素,但对干扰素α给药后出现的不安、失眠、焦躁等症状,甚至有企图自杀的病例较少注意。因此服药时与用药后均应十分注意患者的精神状态和行为的变化。如果在服药时出现变化,就应立即停药然后观察其行为。
Certain functional status resulting from the use of interferon alpha (IFN) preparations, as well as cases of attempted suicide in exceptional circumstances, are documented in the drug user’s manual and should be brought to the attention of medical practitioners. To date, there have been 32 cases of attempted suicide due to the use of interferon alpha, 12 of whom committed suicide and should arouse the vigilance of medical workers in the future. Drug and attempted suicide in the past to consider more of the original disease, past history, the patient’s personality and other uncertain factors, but after the administration of interferon alpha appear uneasy, insomnia, irritability and other symptoms, and even Less attention was paid to attempted suicide. Therefore, medication and medication should pay great attention to the patient’s mental state and behavior changes. If there is a change while taking the medication, stop the medication immediately and observe its behavior.