在实验室近交的啮齿动物中,许多品系的雌性排斥同一品系雄性的皮肤移植物。同一品系内的雄性→雄性,雌性→雌性,以及雌性→雄性的皮肤移植物是可以接受的。雄性特异性排斥于1955年首次报告,随后,相关的雄性特异性组织相容性抗原被命名为HY(组织相容性Y),该名反应了当时人们普遍认为其结构基因位于Y染色体 In the laboratory inbred rodents, many of the female strains of the line reject the same line of male skin grafts. Male → male, female → female, and female → male skin grafts in the same line are acceptable. Male-specific rejection was first reported in 1955, and subsequently, the associated male-specific histocompatibility antigen was named HY (histocompatibility Y), a response that was then thought to be structurally located on the Y chromosome