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本文采用绒毛直接法制备人工流产组绒毛染色体标本30例,RU486药物流产组染色体标本25例,用MI=细胞分裂中期相数/全部细胞数×100％公式计算有丝分裂指数。人工流产组绒毛的MI为0.933 RU486药物流产组绒毛的MI为0.720,经统计学分析,两者差异具显著意义(P<0.05)。实验结果表明:RU486作用蜕膜孕酮受体致使绒毛变性,从而影响其有丝分裂。但不具绒毛染色体损伤效应。
In this study, 30 cases of abortion chorionic ascites and 25 cases of RU486 abortion were prepared by villus direct method. The mitotic index was calculated by the formula of MI = mid-stage cell division / total cell count × 100%. The MI of the abortion group was 0.933 RU486, the MI of the abortion group was 0.720, and the difference was significant (P <0.05) by statistical analysis. Experimental results show that: RU486 decidual progesterone receptor induced villi degeneration, thus affecting their mitosis. But not choroid chromosome damage effect.