论文部分内容阅读
本研究对三种类型EHF疫区固定人群的抗体连续三年检测,以抗体累计阳性法统计分析,发现三种疫区人群均可通过自然感染获得动态的免疫屏障。家鼠型疫区流行过后人群抗体水平较高,但人群累计抗体流行率增长较慢;而有野鼠的疫区人群抗体水平虽较低,但因仍继续潜在流行1～2年,从而家、混、野三类疫区人群抗体流行率分别可达16.92％、18.43％和19.22％的相近水平。当人群抗体流行率达1～2万/10万(即10～20％)时,该病的流行即趋于减弱或停止,证明EHF可以形成一定的自然免疫屏障。只有这种屏障被易感人群的累积所冲破才有可能再次流行。并认为个体有1:20的EHFIgG抗体可防止再次感染,且抗体无论阴转与否3～5年间仍有免疫力。基此,亦为人群和个体人工免疫的可行性提供了有力证据。
In this study, three types of EHF epidemic-fixed population of antibodies for three consecutive years of detection, antibody positive cumulative statistical analysis found that the three epidemic areas of population through natural infection to obtain a dynamic immune barrier. After the prevalence of house-pest-type epidemic areas, the level of antibody in the population is relatively high, but the prevalence of the cumulative antibody in the population has been slow to increase. However, the level of antibody in the population of the plague-bearing area is relatively low. However, The prevalence of antibody among the three types of epidemic areas in the mixed and wild areas reached 16.92%, 18.43% and 19.22% respectively. When the population prevalence of antibodies 1 to 2 million / 100,000 (ie 10 to 20%), the prevalence of the disease tends to be weakened or stopped, that EHF can form a certain natural immune barrier. It is only when this barrier is broken by the accumulation of susceptible people that it is likely to re-emerge. And that the individual has 1:20 EHFIgG antibodies can prevent re-infection, and antibody whether negative or 3 to 5 years still have immunity. In the meantime, this also provides strong evidence of the feasibility of artificial immunity for both the population and individuals.