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患者44岁,女性。1979年诊断为系统性硬皮病(PSS)。1988年4月因劳动时呼吸困难入院。初诊双侧下肺野有杂音,胸片可见心脏肥大和肺静脉扩张,双侧下肺野有粒状阴影。呼吸机能检查肺一氧化碳弥散量(DLCO)为9.5(ml/m in/torr),正常为22.9,肺活量比降至66.7%,有肺限制性障碍。心超声可见中度心包积液。甲状腺机能检查T_3、T_4呈低值,促甲状腺激素(TSH)高值,甲状腺试验、微粒体试验为异常高值。按Casas等的方法静脉点滴5-FU。最初5次每日750mg,此后5次隔日500mg。
44 years old, female. 1979 was diagnosed as systemic scleroderma (PSS). 1988 April due to dyspnea during labor admission. Newly diagnosed bilateral lung field noise, chest X-ray shows cardiac hypertrophy and pulmonary vein dilatation, bilateral lung field under the granular shadow. Respiratory function tests showed a diffuse lung volume (DLCO) of 9.5 (ml / m in / torr), a normal level of 22.9, and a decrease in vital capacity ratio of 66.7%. Echocardiography showed moderate pericardial effusion. Thyroid function tests T_3, T_4 showed low values, thyroid stimulating hormone (TSH) high value, thyroid test, microsomal test abnormal high value. 5-FU was intravenously administered by the method of Casas et al. The first 5 times a day 750mg, after 5 times every other day 500mg.