论文部分内容阅读
以人类白细胞抗原（ＨＬＡ）为遗传标志，选用８个随机婚配的氨基糖甙类耳中毒（以下简称耳中毒）家庭，测定其ＨＬＡ抗原型别，根据分型结果进行连锁分析（Ｌｏｄｓ法）、单倍型分离分析和患病同胞对的分析。结果表明，家族性耳中毒易感基因很可能与ＨＬＡ基因连锁，并以显性方式遗传。
Using HLA as a genetic marker, eight randomly selected families of aminoglycoside ototoxicity (hereinafter referred to as ototoxicity) were selected to determine the type of HLA antigen. According to the typing results, a linkage analysis (Lods method) Haplotype segregation analysis and analysis of diseased sib pairs. The results show that familial ototoxicity susceptible genes are likely to be linked to HLA genes and dominantly inherited.