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目的探讨髓母细胞瘤中β-连环蛋白(β-catenin)、血管内皮生长因子受体-2(Vascular endothelia growth factorreceptor-2,VEGFR-2)和SUFU(Suppressor of fused)的表达及其相关性。方法采用免疫组化SP法检测33份髓母细胞瘤和10份瘤旁正常小脑组织中β-catenin、VEGFR-2和SUFU的表达情况,并分析三者之间表达的相关性。结果33份髓母细胞瘤组织中,β-catenin、VEGFR-2和SUFU的阳性率分别为66.7%(22/33)、87.9%(29/33)和30.3%(10/33),正常小脑组织中的阳性率分别为10%(1/10)、10%(1/10)和90%(9/10),髓母细胞瘤中3种蛋白的表达与正常小脑组织比较,差异均有统计学意义(P<0.05或P<0.01);髓母细胞瘤中β-catenin与VEGFR-2的表达呈正相关,与SUFU的表达呈负相关。结论β-catenin、VEGFR-2和SUFU与髓母细胞瘤的发生发展密切相关。
Objective To investigate the expression of β-catenin, VEGFR-2 and SUFU (Suppressor of fused) in medulloblastoma and its correlation . Methods The expressions of β-catenin, VEGFR-2 and SUFU in 33 medulloblastoma and 10 normal cerebrum tissues were detected by immunohistochemical SP method. The correlation between them was analyzed. Results The positive rates of β-catenin, VEGFR-2 and SUFU in 33 medulloblastomas were 66.7% (22/33), 87.9% (29/33) and 30.3% (10/33), respectively. The normal cerebellum The positive rates in the tissues were 10% (1/10), 10% (1/10) and 90% (9/10), respectively. The expression of three proteins in medulloblastoma was significantly lower than that in normal cerebellum Statistically significant (P <0.05 or P <0.01). The expression of β-catenin and VEGFR-2 in medulloblastoma was positively correlated with the expression of SUFU. Conclusion β-catenin, VEGFR-2 and SUFU are closely related to the development of medulloblastoma.