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目的观察人工周期疗法联合小剂量左甲状腺素钠片治疗卵巢早衰的效果。方法将86例卵巢早衰患者随机分为观察组和对照组各43例。对照组使用人工周期疗法,观察组在对照组基础上联合小剂量甲状腺素片治疗,比较2组临床疗效、血清性激素水平变化及不良反应。结果观察组总有效率为79.07%明显高于对照组的58.14%,差异有统计学意义(P<0.05)。治疗后2组患者血清促卵泡激素(FSH)水平均下降,雌二醇(E2)水平均升高,且观察组变化幅度均大于对照组,差异均有统计学意义(P<0.01)。2组不良反应发生率比较差异无统计学意义(P>0.05)。结论人工周期疗法联合小剂量左甲状腺素钠片治疗卵巢早衰效果显著,可改善血清性激素水平,安全性高,值得推广。
Objective To observe the effect of artificial cycle therapy combined with low-dose levothyroxine sodium tablets in the treatment of premature ovarian failure. Methods 86 cases of premature ovarian failure were randomly divided into observation group and control group, 43 cases each. The control group was treated with artificial cycle therapy. The observation group was treated with small dose of thyroxine on the basis of the control group. The clinical effects, changes of serum sex hormone levels and adverse reactions in the two groups were compared. Results The total effective rate of the observation group was 79.07%, which was significantly higher than that of the control group (58.14%), the difference was statistically significant (P <0.05). Serum follicle-stimulating hormone (FSH) levels and estradiol (E2) levels were increased in both groups after treatment, and the changes in the observation group were greater than those in the control group, with significant differences (P <0.01). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion The combination of artificial cycle therapy and low-dose levothyroxine sodium tablets in the treatment of premature ovarian failure has a significant effect and can improve serum sex hormone levels, which is safe and worthy of promotion.