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[目的]调查和分析乙肝疫苗的免疫效果。[方法]乙肝抗原、抗体的定量测定。[结果]有85.98%的儿童产生了免疫应答,高应答率为43.34%,无应答率为13.67%,抗体浓度呈逐年下降趋势,且以1.5岁后明显,与1岁前比差异有统计学意义。两性之间对比,无论从应答率还是抗体浓度均无统计学差异。[结论]免费乙肝疫苗的接种是安全有效的。探讨是否可通过加大疫苗剂量或改变疫苗佐剂来提高高应答率而减少免疫失败。建议临床工作者在儿童完成乙肝疫苗后定期进行抗体浓度测定。
[Objective] To investigate and analyze the immune effect of hepatitis B vaccine. [Method] The quantitative determination of hepatitis B antigen and antibody. [Results] There were 85.98% of the children had an immune response, the high response rate was 43.34%, the non-response rate was 13.67%, the antibody concentration showed a downward trend year by year, and after 1.5 years of age significantly compared with 1 year before the difference was statistically significance. Comparison between the sexes, no matter from the response rate or antibody concentration were no significant difference. [Conclusion] Vaccination of free hepatitis B vaccine is safe and effective. To investigate whether immune failure can be reduced by increasing the vaccine dose or changing the vaccine adjuvant to increase the high response rate. It is recommended that clinicians routinely conduct antibody concentration determination after children complete hepatitis B vaccine.