一、定义由于垂体,下丘脑内分泌特殊形式的紊乱使非产褥期的非哺乳妇女,一侧或双侧乳头持续排出乳汁伴长期闭经称为闭经溢乳综合征.二、泌乳生理(一)乳汁的生成和排出:在乳腺发育及泌乳过程中,催乳素(PRL)、雌激素、孕激素、甲状腺素及肾上腺皮质素均起作用.其中最重要的是PRL和雌、孕激素.孕期,PRL升高刺激乳腺腺泡合成及分泌乳汁;雌激素升高刺激腺管发育,孕激素刺激腺泡发育但二者抑制乳汁的分泌.胎盘娩出后,大部分雌、孕激素来源突然排除,解除了抑制乳汁分泌的作用,而PRL持续分泌.于是乳汁的合成和分泌被启动.乳汁的喷射是由乳头受刺激引起的反射.刺激通过下丘脑作用于垂体后叶,使其释放催产素引起乳腺肌上皮细胞的收缩,使乳汁排入输乳管.(二)PRL1.结构:PRL是由垂体催乳素细胞分泌 First, the definition of the pituitary, hypothalamic endocrine due to a special form of disorder in non-puerperium non-lactating women, one or both sides of the nipple continuous discharge of milk with long-term amenorrhea called amenorrhea galactorrhea syndrome. And excretion: PRL, estrogen, progesterone, thyroxine and adrenocortin play a role in mammary development and lactation, among which PRL and estrogen and progesterone are the most important, PRL is elevated during pregnancy Stimulation of mammary acinar synthesis and secretion of milk; estrogen to stimulate the development of the gland, progesterone stimulate the development of the alveolus but both inhibit the secretion of milk.After the delivery of the placenta, most of the estrogen and progesterone sources suddenly ruled out the inhibition of milk Secretion and the role of PRL secretion continued.Then the synthesis and secretion of milk was activated.The injection of milk is caused by the stimulation of the nipple reflex.Stimulation through the hypothalamus in the posterior pituitary gland to make it release oxytocin caused by mammary gland epithelial cells Contraction, so that milk into the ducts. (B) PRL1. Structure: PRL is secreted by the pituitary prolactin cells