目的了解中国人结直肠癌p53基因缺失的情况。方法应用Southern印迹杂交技术检测24例结直肠癌p53基因缺失。结果发现24例结直肠癌中10例(41.7%)存在p53基因缺失,且发生淋巴结扩散和远处转移的结直肠癌中,p53基因缺失率较高(分别为60%和66.67%)。结论 p53基因缺失是结直肠癌的一种常见的分子结构改变,可能在结直肠癌的发生和发展中起着重要的作用。 Objective To understand the p53 gene deletion in Chinese colorectal cancer. Methods Southern blot hybridization was used to detect p53 gene deletion in 24 cases of colorectal cancer. The results showed that in 24 cases of colorectal cancer, 10 cases (41.7%) had p53 gene deletion, and in the colorectal cancer with lymph node spread and distant metastasis, the p53 gene deletion rate was higher (60% and 66.67%, respectively). Conclusion The deletion of p53 gene is a common molecular structure change in colorectal cancer, which may play an important role in the occurrence and development of colorectal cancer.