为研制肝内胆管结石模型,将实验兔分为4组:①正常对照组,②单纯胆总管内注菌组,③单纯胆总管结扎组,④胆总管结扎加注菌组。实验结果显示,第1、2组均未形成结石,第4组的成石率为60.0%,明显高于第3组(25.0%)。结石实验兔的受累肝脏和胆道系统均有不同程度的化脓性变化,胆汁成分有明显改变,讨论了其对结石的影响。 To develop intrahepatic bile duct stones model, the experimental rabbits were divided into 4 groups: 1 normal control group, 2 simple common bile duct injection group, 3 simple common bile duct ligation group, and 4 common bile duct ligation plus bacteria group. The experimental results showed that no stones were formed in the first and second groups, and the stone formation rate in the fourth group was 60.0%, which was significantly higher than that in the third group (25.0%). In rabbits, the affected livers and biliary tracts of rabbits had different degrees of suppurative changes, and the bile composition had significant changes. The effects on stones were discussed.