继1972年丁胺卡那霉素合成成功并发现其独特特性后,人们非常期望能合成出或从土壤细菌中筛选出抗菌力更强、抗菌谱更广的氨基糖苷类抗生素。以后增加了研究课题,开始了一些新的计划。这些努力确实证明是对的,因为在过去十年中氨基糖苷类确实是治疗严重病员的重要武器。作为一大类药物 Following the successful synthesis of amikacin in 1972 and the discovery of its unique properties, it is highly expected that aminoglycoside antibiotics will be synthesized or screened from soil bacteria for greater antibacterial activity and broader antibacterial spectrum. Later added research topics and started some new programs. These efforts prove to be correct, as aminoglycosides have indeed been an important weapon in the treatment of serious illnesses in the past decade. As a large class of drugs