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目的探讨人表皮生长因子受体2(HER-2)和Ki-67在胃癌组织中的表达及临床意义。方法回顾性分析647例胃癌患者的临床资料,分析HER-2和Ki-67的表达与临床病理特征的关系。结果胃癌组织中HER-2和Ki-67的阳性表达率分别为23.6%和84.9%。HER-2的表达与淋巴结转移、TNM分期、浸润深度和脉管浸润有关(P<0.05)。Ki-67的表达与TNM分期和浸润深度有关(P<0.05或P<0.01)。HER-2和Ki-67共表达与淋巴结转移、TNM分期、浸润深度有关(P<0.01)。尚未发现HER-2和Ki-67的表达存在相关关系(r=0.039,P>0.05)。结论 HER-2和Ki-67的表达与胃癌的发生、发展密切相关,两者的联合检测有助于评估胃癌的恶性程度和患者的预后。
Objective To investigate the expression and clinical significance of human epidermal growth factor receptor 2 (HER-2) and Ki-67 in gastric cancer. Methods The clinical data of 647 patients with gastric cancer were retrospectively analyzed. The relationship between the expression of HER-2 and Ki-67 and clinicopathological features was analyzed. Results The positive rates of HER-2 and Ki-67 in gastric cancer tissues were 23.6% and 84.9% respectively. The expression of HER-2 was correlated with lymph node metastasis, TNM stage, depth of invasion and vascular invasion (P <0.05). Ki-67 expression was correlated with TNM stage and depth of invasion (P <0.05 or P <0.01). The co-expression of HER-2 and Ki-67 was correlated with lymph node metastasis, TNM stage and depth of invasion (P <0.01). No correlation was found between HER-2 and Ki-67 (r = 0.039, P> 0.05). Conclusions The expressions of HER-2 and Ki-67 are closely related to the occurrence and development of gastric cancer. The combined detection of HER-2 and Ki-67 may be helpful to evaluate the malignant degree of gastric cancer and the prognosis of patients.