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目的研究胃癌组织中ＥＢ病毒感染情况，初步探讨ＥＢ病毒感染与胃癌的关系。方法采用ＲＮＡ原位杂交法观察５８例胃腺癌，２７例胃癌癌前病变及１５例正常胃粘膜组织中ＥＢ病毒感染发生率和分布情况。结果胃癌组织ＥＢ病毒感染阳性率为１０．３％，阳性标本多属低分化腺癌；胃癌癌前病变、正常胃粘膜及癌旁粘膜ＥＢ病毒检测均阴性。结论ＥＢ病毒在胃癌发病中的作用可能是有限的，其主要致病因素有待进一步阐明
Objective To study the infection of Epstein-Barr virus (EBV) in gastric cancer and to explore the relationship between Epstein-Barr virus infection and gastric cancer. Methods RNA in situ hybridization was used to observe the incidence and distribution of Epstein-Barr virus infection in 58 cases of gastric adenocarcinoma, 27 cases of gastric precancerous lesions and 15 cases of normal gastric mucosa. Results The positive rate of Epstein-Barr virus infection in gastric cancer was 10.3%. Most of the positive samples were poorly differentiated adenocarcinoma. The precancerous lesions of gastric cancer, normal gastric mucosa and paraneoplastic mucosa were negative. Conclusion The role of EB virus in the pathogenesis of gastric cancer may be limited, and its main pathogenic factors need further elucidation.