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自1986年11月至1988年6月对住院的成人患者经肝穿病理确诊为慢性活动型肝炎,并经血清学证实为乙型肝炎共86例,均符合1984年12月南宁全国肝炎会议制订的临床及病理诊断标准。随机分为3组:小柴胡汤组、小柴胡汤加联苯双酯组及联苯双酯组。3组连续服用药物3个月为一疗程。经临床观察,初步证明小柴胡汤与联苯双酯有相同的降低谷丙转氨酶的作用;12例患者中,有9例DNA多聚酶(DNA-P)阴转,治疗前后有显著差异(P<0.01),与动物实验结论一致。小柴胡汤对治疗慢性活动型肝炎有一定价值,值得进一步研究。
From November 1986 to June 1988 adult patients admitted to the hospital were diagnosed as chronic active hepatitis by pathological liver biopsy, and confirmed by serological analysis of hepatitis B in 86 cases, all in line with the 1984 Nanning National Hepatitis Conference to develop The clinical and pathological diagnostic criteria. Randomly divided into 3 groups: Xiao Chai Hu Tang group, Xiao Chai Hu Tang plus bifendate group and bifendate group. 3 groups taking drugs for 3 months for a course of treatment. Preliminary clinical evidence shows that Xiaochaihu decoction and bifendate have the same effect of reducing alanine aminotransferase (ALT); among the 12 patients, 9 DNA polymerase (DNA-P) are negative and have significant difference before and after treatment (P < 0.01), consistent with animal experiments. Xiao Chai Hu Tang for the treatment of chronic active hepatitis has some value, it is worth further study.