合适的动物发热模型,对于筛选和研究解热药至为重要。常用方法为给家兔注射细菌毒素或啤酒酵母,但用于筛选试验甚不经济。有报道小动物发热方法,但在应用时常不能得到原作者报道的类似结果。我们在工作中发现应用国内生产的酵母粉,对大鼠有明显发热作用。一、方法与结果雄性小鼠,体重20～30g。雄或雌性大鼠,体重150～200g。动物在试验前1天预先分笼, Proper animal fever models are important for screening and studying antipyretics. The common method is to inject rabbits with bacterial toxins or brewer’s yeast, but it is less economical to use for screening tests. There are reports of small animal fever method, but in the application often can not get the original authors to report similar results. We found at work that yeast produced domestically was used to produce significant fever in rats. First, methods and results Male mice weighing 20 ~ 30g. Male or female rats weighing 150-200 g. Animals were pre-divided 1 day before the test,