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[目的]探讨多元方差分析和混合效应线性模型在处理临床手术追踪数据中的应用,以评估不同手术方式对改善患者症状和生活质量的影响,从而得出更可靠、更科学的专业结论。[方法]通过健康调查简表(the MOS item short from health survey,SF-36)对38例慢性鼻窦炎鼻息肉患者术前、术后1个月和术后6个月进行随访调查,以总体健康得分为评价指标,并运用统计软件进行分析,比较采取不同范围的手术方式对患者进行治疗的效果。[结果]经手术治疗,患者术后1个月总体健康状况开始出现好转(P﹤0.01)。而不同范围的手术方式对患者症状和QOL状态影响的差别无统计学意义(P﹥0.05)。[结论]术后1个月患者症状基本改善,而不同范围手术对病变范围相同或相似患者症状和生活质量的改善基本相同,建议选用改良型鼻内镜手术。
[Objective] To explore the application of multivariate analysis of variance (ANOVA) and mixed-effects linear model in clinical operation tracking data to evaluate the effect of different surgical methods on improving the symptoms and quality of life of patients, thus leading to more reliable and scientific professional conclusions. [Methods] 38 patients with chronic sinusitis and nasal polyps underwent preoperative, postoperative 1 month and postoperative 6 months follow-up survey through the MOS item short from health survey (SF-36) Health score as an evaluation index, and the use of statistical software for analysis, to compare the different types of surgical treatment of patients with the effect. [Results] After operation, the overall health status of the patients started to improve at one month after operation (P <0.01). There was no significant difference in the effect of different surgical methods on the symptoms and QOL status (P> 0.05). [Conclusions] The symptom of one month after operation basically improved, and the improvement of symptom and quality of life of patients with the same or similar lesion range were basically the same in different range of operation. We suggest using modified endoscopic surgery.