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目的比较递减疗法与持续低剂量疗法吸入丙酸氟替卡松(FP)治疗哮喘的疗效。方法选择100例哮喘患者,对照组50例使用递减法,试验组50例使用持续低剂量法,以乙酰甲胆碱激发试验和诱导痰嗜酸粒细胞计数评价治疗效果。结果与治疗前相比,两组患者治疗14周后使第一秒呼气容积(FEV_1)下降20%基础值的乙酰甲胆碱激发剂量(PD_(20))[(对照组(859±389)μg、试验组(835±398)μg]及嗜酸粒细胞[(对照组(3.07±3.84)%、试验组(4.32±5.02)%],差异有显著性意义(P<0.05),两组 PD_(20)值及嗜酸粒细胞差异无显著性意义(P>0.05)。结论用 FP 递减疗法与持续低剂量疗法治疗哮喘患者对改善 PD_(20)和痰液嗜酸粒细胞具有相同的效果。
Objective To compare the efficacy of descending therapy and continuous low-dose inhalation of fluticasone propionate (FP) in the treatment of asthma. Methods 100 cases of asthma patients, control group 50 cases using the decrement method, 50 cases of the experimental group using continuous low dose method to methacholine challenge test and induced sputum eosinophil count evaluation of the therapeutic effect. RESULTS: After 14 weeks of treatment, the first-second expiratory volume (FEV_1) was decreased by 20% of the basal value of methacholine challenge dose (PD_ (20)) [control group (859 ± 389 ) in the experimental group (835 ± 398) μg] and eosinophils (3.07 ± 3.84% in the control group and 4.32 ± 5.02% in the experimental group), and the difference was significant (P <0.05) There was no significant difference between the values of PD_ (20) and eosinophils (P> 0.05) .Conclusions The treatment of asthmatic patients with FP-down therapy and continuous low-dose therapy has the same effect on improving PD_ (20) and sputum eosinophil Effect.