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下丘是听觉信号的加工中枢,γ-氨基丁酸是其中的主要抑制性神经递质,在下丘的声音频率分析、时间和空间编码中具有重要作用。耳鸣的形成可能与传入下丘的γ-氨基丁酸介导的抑制性神经活动减弱,从而导致听皮层的过度兴奋性活动有关,大量研究发现与兴奋性水平相比,影响下丘神经元的相关的抑制性水平随年龄而下降,可能是老年性耳鸣的形成原因。下丘中神经递质的变化可能是一种慢性的、渐进性的神经阻滞所导致的外周输入信息的丧失。兴奋性神经递质随年龄缺乏变化,它们在老年性耳鸣中的作用少见报道。
The inferior colliculus is the processing center of auditory signals, and γ-aminobutyric acid is one of the major inhibitory neurotransmitters, which plays an important role in the acoustic frequency analysis, temporal and spatial coding of the inferior colliculus. The formation of tinnitus may be related to the attenuation of γ-aminobutyric acid-mediated inhibitory neurotransmission introduced into the inferior colliculus, which results in the over-excitement activity of the auditory cortex. Numerous studies have found that the effects of inferior amygdala neurons The related inhibitory levels decreased with age, which may be the cause of senile tinnitus. Changes in neurotransmitters in the inferior colliculus may be a consequence of chronic, progressive neurological blockade in the loss of peripheral input. Excitatory neurotransmitters lack change with age and their role in senile tinnitus is seldom reported.